Sean Edward Lawler

This study evaluates Brincidofovir's effects on glioblastoma, showing improved survival and both CMV-dependent and independent antitumor activity.

This paper demonstrates that combining oncolytic adenovirus encoding bispecific T cell engager (OV-BiTE) with CAR-T cells enhances T cell recruitment and tumor eradication in glioblastoma xenograft models.

This study shows that MK2 regulates CD8 T cell inflation during CMV infection by affecting their expansion and differentiation.

The paper shows that miR-181d degradation via a PNPT1-ATR feed-forward loop increases MGMT expression variance, leading to temozolomide resistance in glioblastoma cells.

This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.

This paper develops a high-throughput BTB assembloid model to study glioblastoma-neurovascular interactions and therapeutic responses, finding that BTB disruption correlates with increased tumor invasiveness and drug resistance.

This study identifies Nogo-A as an onco-fetal protein that inhibits glioma vascularization and growth through VEGF-Notch-Hippo-metabolic signaling in human and mouse models.

This study identifies Nucleolin as a factor reactivated in gliomas that promotes angiogenesis and endothelial metabolism by regulating glycolysis through p53-TIGAR-HK2.