Author

Moheb Ghobrial

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Ivan RadovanoviciD· 4 shared Philippe Patrick MonnieriD· 4 shared Thomas WälchliiD· 4 shared Karl Frei· 3 shared Katrien De BockiD· 3 shared Marc Schwab· 3 shared Ralph SchlapbachiD· 3 shared Daniela VirgintinoiD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersNeuroscience

Ivan RadovanovicORCID

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4 papers

Recent·Most cited

Onco-fetal protein Nogo-A restricts human and mouse glioma vascularization and growth via VEGF-Notch-hippo-metabolic signaling

Marc Schwab, Moheb Ghobrial, Jorge L. Jimenez-Macias, Michał Beffinger, Yanrong Ji, Andrin Wacker, Hidekiyo Harada, Jau-Ye Shiu, Oskar Novitzki, Ignazio de Trizio, Francesco Girolamo, Mariella Errede, Tobias Weiß, Dorothee Gramatzki, Miguel Maurer, , Thomas Wälchli

This study identifies Nogo-A as an onco-fetal protein that inhibits glioma vascularization and growth through VEGF-Notch-Hippo-metabolic signaling in human and mouse models.

bioRxiv · Oct 2, 2024 · PreprintNeuroscience

Molecular atlas of the human brain vasculature at the single-cell level

Thomas Wälchli, Moheb Ghobrial, Marc Schwab, Shigeki Takada, Hang Zhong, Samuel Suntharalingham, Sandra Vetiska, Daymé Rodrigues Rodrigues, Hubert Rehrauer, Ruilin Wu, Kai Yu, Jeroen Bisschop, Fiona Farnhammer, Luca Regli, Karl Schaller, , Ivan Radovanovic

The paper constructs a molecular atlas of the human brain vasculature using single-cell RNA sequencing, revealing molecular heterogeneity and disease-related alterations in vascular cells.

bioRxiv · Oct 18, 2021 · PreprintNeuroscience

Nucleolin is expressed in human fetal brain development and reactivated in human glial brain tumors regulating angiogenesis and vascular metabolism

Marc Schwab, Ignazio de Trizio, Jau-Ye Shiu, Moheb Ghobrial, Oǧuzkan Sürücü, Francesco Girolamo, Mariella Errede, Murat Yilmaz, Johannes Haybaeck, Alessandro Moiraghi, Philippe Patrick Monnier, Sean Edward Lawler, Jeffrey Peter Greenfield, Ivan Radovanovic, Karl Frei, , Thomas Wälchli

This study identifies Nucleolin as a factor reactivated in gliomas that promotes angiogenesis and endothelial metabolism by regulating glycolysis through p53-TIGAR-HK2.

bioRxiv · Oct 14, 2020 · PreprintNeuroscience

The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors

Moheb Ghobrial, Jason Charish, Shigeki Takada, Taufik A. Valiante, Philippe Patrick Monnier, Ivan Radovanovic, Gary D. Bader, Thomas Wälchli

The paper constructs a single-cell atlas of SARS-CoV-2 entry factors and interaction partners in human and mouse brain vasculature, revealing distinct expression patterns of CTSB and CTSL in brain and peripheral vasculature.

bioRxiv · Oct 10, 2020 · PreprintNeuroscience