Inhibition of β-catenin signaling by Amyloid-β in endothelial cells impairs vascular barrier integrity
Joseph W. Leasure, Thi Mai, A.V. Fogel, Pierina Danos-Diaz, Li Wang, Mark A. Sanborn, Zijing Ye, Young-Mee Kim, Xinhe Wang, Jennifer Flores, Muzamil Mushtaq, Péter T. Tóth, Sang‐Ging Ong, Orly Lazarov, Jalees Rehman
This study shows that Amyloid-β inhibits β-catenin signaling in endothelial cells, reducing BBB integrity and contributing to Alzheimer's Disease progression.
bioRxiv · Nov 5, 2024 · PreprintNeuroscience