Orly Lazarov

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer's Disease phenotypes associated with Down Syndrome

This study investigates the role of APP overdose in Down Syndrome by reducing APP dosage in DS iPSCs and assessing its impact on neurogenesis and Alzheimer's disease pathology.

Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoids

This study shows that reducing APP gene copy number in Down syndrome cortical organoids improves neural progenitor cell proliferation and neuronal differentiation.

Inhibition of β-catenin signaling by Amyloid-β in endothelial cells impairs vascular barrier integrity

This study shows that Amyloid-β inhibits β-catenin signaling in endothelial cells, reducing BBB integrity and contributing to Alzheimer's Disease progression.

Caveolin-1 Regulates Neurogenesis and Learning and Memory by Modulation of Mitochondrial Dynamics

This study shows that Caveolin-1 regulates neurogenesis and learning by modulating mitochondrial dynamics in neural progenitor cells.