Sang‐Ging Ong

This study identifies PF4 as a key regulator of HSC aging, showing that PF4 deficiency accelerates aging and that PF4 supplementation can rejuvenate aged HSCs.

This study shows that Amyloid-β inhibits β-catenin signaling in endothelial cells, reducing BBB integrity and contributing to Alzheimer's Disease progression.

This study identifies PDGFRβ+ pericytes as developmental brown adipocyte progenitors and shows that inhibiting the Notch/PDGFRβ axis promotes brown adipogenesis and improves metabolic health.

This study shows PPP1R12C overexpression in AF patients and mice leads to MLC2a dephosphorylation, reduced atrial contractility, and increased AF inducibility.

BEdeepon predicts base editor efficiencies and outcome sequences using deep learning models trained on high-throughput screening data.

BEdeepoff predicts off-target editing efficiencies for ABE and CBE base editors using deep learning models trained on high-throughput screening data.