Ancestral tributyltin exposure produces male-specific brown adipose thermogenic dysregulatoin
Yikai Huang, Richard Cheng-An Chang, Katelyn U Nguyen, Kaitlin To, Myah Gibbs, Harunori Honjoh, Toshi Shioda, Bruce Blumberg
This study shows that ancestral tributyltin exposure impairs male brown adipose thermogenic function, leading to increased fat accumulation and reduced mitochondrial capacity after high-fat diet.
bioRxiv · Nov 4, 2025 · PreprintPharmacology & Toxicology