Author

Yikai Huang

University of California, IrvineORCID 0009-0005-5541-0618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bruce BlumbergiD· 2 shared Richard Cheng-An ChangiD· 2 shared Toshi ShiodaiD· 2 shared Angela NguyeniD· 1 shared Angélica Amorim AmatoiD· 1 shared Erika M. JoloyaiD· 1 shared Hailey Brit Wheeler· 1 shared Harunori HonjohiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPharmacology & Toxicology

Bruce BlumbergORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintNov 4, 2025

Ancestral tributyltin exposure produces male-specific brown adipose thermogenic dysregulatoin

Yikai Huang, Richard Cheng-An Chang, Katelyn U Nguyen…·Bruce Blumberg

This study shows that ancestral tributyltin exposure impairs male brown adipose thermogenic function, leading to increased fat accumulation and reduced mitochondrial capacity after high-fat diet.

DOI 10.1101/2025.11.04.686561

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintOct 27, 2022

Heritable changes in chromatin contacts linked to transgenerational obesity

Richard Cheng-An Chang, Riann Jenay Egusquiza, Yikai Huang…·Bruce Blumberg

This study shows that exposure to the obesogen tributyltin causes heritable changes in chromatin structure in germ cells, leading to transgenerational obesity in male offspring.

8 citations

mouseChIP-seq

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