Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron-microglia co-culture model
Dolores Siedlecki‐Wullich, Anne‐Marie Ayral, Lukas da Cruz Carvalho Iohan, Célia Lemeu, Valérie Buiche, K. Blary, Julien Chapuis, Fanny Eysert, Delphine Beury, Myriam Delacre, David Hot, Takahiro Masuda, Klaus‐Peter Knobeloch, Marco Prinz, Jean‐Charles Lambert, Devrim Kilinc
This paper develops a microfluidic co-culture model to study microglial synapse phagocytosis in AD, finding that APP microglia show enhanced synaptic uptake under inflammation.
bioRxiv · Aug 19, 2025 · PreprintNeuroscience