Takahiro Masuda

This study develops an organotypic neocortical slice culture to study neuroglial interactions across development and disease states.

This study identifies ZFP384 as a regulator that impairs microglial reparative function after stroke, and shows that targeting ZFP384 enhances recovery even in the chronic phase.

This study identifies a role for subarachnoid macrophages in amyloid-beta clearance and vascular dysfunction in Alzheimer's disease using mouse models and intravital imaging.

The paper uses spatial proteomics to identify projection-specific molecular diversity in the prefrontal cortex and identifies BLTP2 as a key presynaptic protein involved in memory and behavior.

This paper develops a microfluidic co-culture model to study microglial synapse phagocytosis in AD, finding that APP microglia show enhanced synaptic uptake under inflammation.

This study shows that IL-4 increases CD11c+ microglia in the spinal dorsal horn, which ameliorates neuropathic pain in mice.

This study identifies five myeloid cell types in the mouse cochlea using single-cell transcriptomics, fate mapping, and parabiosis, revealing their spatial distribution, ontogeny, and functional diversity.

This study converts microglia/macrophages into neurons in the injured brain to restore neurological function after stroke.

This study evaluates four microglial inducible Cre lines, showing differences in recombination efficiency and spontaneous recombination, and provides best practices for measuring these in microglia.

This study shows that 10 Hz rTMS induces synaptic plasticity via microglia-released cytokines, with TNF and IL6 playing a key role.