Author

Valérie Buiche

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Jean‐Charles LambertiD· 2 shared Julien ChapuisiD· 2 shared Ana Melo de Farias· 1 shared Angelika DannertiD· 1 shared Anne‐Marie AyraliD· 1 shared Audrey CouloniD· 1 shared Benjamin Grenier‐BoleyiD· 1 shared Bruno Neiva-Queirós· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Jean‐Charles LambertORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

Nina lannette-Weimann, Marlène Huyvaert, Floriane Limoge, Morgane Lemaire, Vance Difan Gao, Florence Maurier, Karine Guyot, Charlotte Henocq, Audrey Coulon, Valérie Buiche, Florian Rabiller, Nad’a Majerníková, Pauline Walle, Sophie Desnoulez-Salomé, Bruno Neiva-Queirós, , Julie Dumont

This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.

bioRxiv · Oct 30, 2026 · PreprintGenetics

Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron-microglia co-culture model

Dolores Siedlecki‐Wullich, Anne‐Marie Ayral, Lukas da Cruz Carvalho Iohan, Célia Lemeu, Valérie Buiche, K. Blary, Julien Chapuis, Fanny Eysert, Delphine Beury, Myriam Delacre, David Hot, Takahiro Masuda, Klaus‐Peter Knobeloch, Marco Prinz, Jean‐Charles Lambert, Devrim Kilinc

This paper develops a microfluidic co-culture model to study microglial synapse phagocytosis in AD, finding that APP microglia show enhanced synaptic uptake under inflammation.

bioRxiv · Aug 19, 2025 · PreprintNeuroscience