Marco Prinz

This study investigates the role of USP8 in B-cell development and multiple myeloma, showing its impact on proteostasis and identifying potential therapeutic strategies.

This paper introduces coding agents that generate interpretable single-cell embeddings from literature-based gene programs without training data or databases.

This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.

This study identifies hypoxia-associated transcriptional plasticity in IDH-mutant gliomas, showing microglia-driven quiescent-to-activated transitions that drive malignant progression.

This paper shows that loss of IFNAR1 in neurons and astrocytes disrupts brain energy metabolism and leads to Parkinsonian dementia-like features in mice.

This study develops an organotypic neocortical slice culture to study neuroglial interactions across development and disease states.

This study identifies ZFP384 as a regulator that impairs microglial reparative function after stroke, and shows that targeting ZFP384 enhances recovery even in the chronic phase.

The paper identifies socially regulated genes in ants that show increased 3D chromatin contacts with enhancers, suggesting pre-existing connectivity supports brain plasticity during caste transition.

This study maps the postnatal differentiation trajectories of dendritic epidermal T cells and Langerhans cells in mice, showing they develop independently of each other and microbial colonization.

This study identifies a role for subarachnoid macrophages in amyloid-beta clearance and vascular dysfunction in Alzheimer's disease using mouse models and intravital imaging.

This study identifies an iron-associated mesenchymal subpopulation in GBM that drives invasion and is linked to poor patient survival.

This paper develops a microfluidic co-culture model to study microglial synapse phagocytosis in AD, finding that APP microglia show enhanced synaptic uptake under inflammation.

This study shows that dermal macrophages can maintain functional diversity without monocyte replenishment, but require monocytes during bacterial infections.

This study identifies five myeloid cell types in the mouse cochlea using single-cell transcriptomics, fate mapping, and parabiosis, revealing their spatial distribution, ontogeny, and functional diversity.

This study examines myelination patterns in FCD IIa and IIb in the frontal lobe, finding divergent maladaptive myelination features between the two subtypes.

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

This study converts microglia/macrophages into neurons in the injured brain to restore neurological function after stroke.

This study evaluates four microglial inducible Cre lines, showing differences in recombination efficiency and spontaneous recombination, and provides best practices for measuring these in microglia.

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

This study shows that 10 Hz rTMS induces synaptic plasticity via microglia-released cytokines, with TNF and IL6 playing a key role.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.