PTK2 regulates the UPS impairment via p62 phosphorylation in TDP-43 proteinopathy
Shinrye Lee, Yu‐Mi Jeon, Seyeon Kim, Younghwi Kwon, Myungjin Jo, You-Na Jang, Seongsoo Lee, Jaekwang Kim, Sang Ryong Kim, Kea Joo Lee, Sung Bae Lee, Kiyoung Kim, Hyung‐Jun Kim
This study identifies PTK2 as a suppressor of TDP-43-induced neurotoxicity by regulating p62 phosphorylation and UPS impairment in neuronal cells.
bioRxiv · Jun 25, 2018 · PreprintNeuroscience