The MYCN/Aurora-A complex is a cyclin activating kinase for CDK12
Mareike Müller, Lorenz Eing, Leonie Uhl, Maximilian Schmitz, Iliyana N. Kaneva, Dominic P. Byrne, Daniel Fleischhauer, Selena G. Burgess, Sophia Fischer, N Gebauer, Vanessa Nancy-Portebois, Ines H. Kaltheuner, Stefanie Ahn Ha, Christina Schülein-Völk, Daniel Solvie, , Gabriele Büchel
This study identifies Aurora-A as a CDK12-activating kinase in neuroblastoma, showing its role in transcription termination and tumor growth suppression.
bioRxiv · Jan 15, 2025 · PreprintCancer Biology