N. A. Lemmermann

Cytomegalovirus inhibitors of programmed cell death prevent a contribution of antigen cross-presentation to the priming of antiviral CD8 T cells

This study shows that cytomegalovirus (CMV) inhibitors of programmed cell death restrict antigen cross-presentation, thereby limiting CD8 T-cell priming in mice.

Direct Antigen Presentation is the Canonical Pathway of Cytomegalovirus CD8 T-cell Priming Regulated by Balanced Immune Evasion Mounting a Strong Antiviral Response

This study investigates how CMV primes CD8 T cells, finding that balanced immune evasion supports optimal antiviral responses despite conflicting evidence on direct antigen presentation's role.

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells