W. Brune

Limited protection against early-life cytomegalovirus infection results from deficiency of cytotoxic CD8T cells

This study shows that deficiency of cytotoxic CD8 T cells in early life leads to limited protection against cytomegalovirus infection.

Cytomegalovirus inhibitors of programmed cell death prevent a contribution of antigen cross-presentation to the priming of antiviral CD8 T cells

This study shows that cytomegalovirus (CMV) inhibitors of programmed cell death restrict antigen cross-presentation, thereby limiting CD8 T-cell priming in mice.

Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophages

This study identifies HCMV glycoprotein variants that determine viral infectivity and syncytium formation in epithelial cells and macrophages.

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication

This paper identifies m139 as a viral gene that targets DDX3 to suppress interferon production and enhance viral replication in macrophages and endothelial cells.

Viral mediated tethering to SEL1L facilitates ER-associated degradation of IRE1

This paper identifies that the viral protein M50 promotes IRE1 degradation via SEL1L-mediated ERAD, dampening the UPR to benefit viral replication.

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

The paper identifies how herpesvirus kinases interact with Cyclin A to inhibit host DNA synthesis during infection.

Repression of Viral Gene Expression and Replication by the Unfolded Protein Response Effector XBP1u

This study shows that MCMV uses the UPR to regulate its life cycle by activating the IRE1-XBP1 pathway to counteract XBP1u repression of viral gene expression and replication.