Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration
H. Hahn, C. Daly, J. Little, N. A. Perry-Hauser, E. Flores-Espinoza, A. Inoue, B. Plouffe, A. R. B. Thomsen
This study shows endosomal chemokine receptor signaling, specifically through CCR7, enhances Rac1 activity and immune T cell chemotaxis by recruiting G protein and β-arrestin.
bioRxiv · Sep 27, 2022Cell Biology