J. Little

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution

The paper characterizes a large collection of Bacteroidales isolates from the human gut, revealing genomic and metabolomic diversity and horizontal gene transfer across species.

Phylogenetic signal in primate tooth enamel proteins and its relevance for paleoproteomics

The paper evaluates the reliability of phylogenetic inference using primate enamel proteins by simulating sequence fragmentation and comparing results to a reference species tree.

Evolutionary Rate Covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions

This study investigates whether evolutionary rate covariation (ERC) signals reflect physical interactions or other factors, finding weak evidence for physical coevolution and suggesting selective pressures may drive the signal.

Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration

This study shows endosomal chemokine receptor signaling, specifically through CCR7, enhances Rac1 activity and immune T cell chemotaxis by recruiting G protein and β-arrestin.