β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
C. Daly, A. A. Guseinov, H. Hahn, A. Wright, I. Tikhonova, A. R. B. Thomsen, B. Plouffe
This study shows the vasopressin type 2 receptor can activate G proteins at endosomes both with and without beta-arrestin, challenging existing models of GPCR signaling.
bioRxiv · Apr 1, 2023Cell Biology