Author

N. A. Zacharewski

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

G. N. Cholico· 1 shared K. A. Fader· 1 shared R. Nault· 1 shared R. R. Fling· 1 shared T. R. Zacharewski· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperPharmacology & Toxicology

G. N. Cholico

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivJan 21, 2021

Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation

G. N. Cholico, R. R. Fling, N. A. Zacharewski…·T. R. Zacharewski

This study shows TCDD induces a futile cycle in hepatic fatty acid metabolism by repressing β-oxidation genes and increasing octenoyl-CoA, which inhibits ECHS1 activity.

DOI 10.1038/s41598-021-95214-0

mousemetabolomics

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