Author

R. R. Fling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

R. Nault· 2 shared T. Zacharewski· 2 shared A. L. Schilmiller· 1 shared G. N. Cholico· 1 shared K. A. Fader· 1 shared K. Orlowska· 1 shared N. A. Zacharewski· 1 shared T. R. Zacharewski· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

R. Nault

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently shifts the gut microbiome consistent with the progression of steatosis to steatohepatitis with fibrosis

R. R. Fling, T. Zacharewski

This study shows that TCDD dose-dependently alters gut microbiota in mice, increasing Lactobacillus species and bile acid metabolism pathways, similar to human NAFLD progression.

bioRxiv · Nov 2, 2021Microbiology

Dioxin-elicited decrease in cobalamin redirects hepatic propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate accumulation

K. Orlowska, R. R. Fling, R. Nault, W. J. Sink, A. L. Schilmiller, T. Zacharewski

This study shows TCDD decreases cobalamin, inhibits MUT activity, and redirects propionyl-CoA metabolism to a Cbl-independent β-oxidation-like pathway, leading to acrylyl-CoA accumulation and hepatotoxicity.

bioRxiv · Mar 24, 2021Pharmacology & Toxicology

Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation

G. N. Cholico, R. R. Fling, N. A. Zacharewski, K. A. Fader, R. Nault, T. R. Zacharewski

This study shows TCDD induces a futile cycle in hepatic fatty acid metabolism by repressing β-oxidation genes and increasing octenoyl-CoA, which inhibits ECHS1 activity.

bioRxiv · Jan 21, 2021Pharmacology & Toxicology