N. Bourg

Identification of bazedoxifene for the treatment of LGMD R2 by high throughput screening.

This study identifies bazedoxifene as a potential treatment for LGMD R2 through high-throughput screening of drugs targeting dysferlin aggregation.

Robust and fast multicolor Single Molecule Localization Microscopy using spectral separation and demixing

This paper evaluates two methods to speed up multicolor SMLM by using spectral separation and demixing, showing their effectiveness in reducing crosstalk and enabling three-dimensional imaging.

Dual blockade of misfolded alpha-sarcoglycan degradation by bortezomib and givinostat combination

This study identifies givinostat as a potential therapeutic for LGMD R3 by inhibiting autophagy and enhancing bortezomib's effect on misfolded alpha-sarcoglycan degradation.

Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in Duchenne muscular dystrophy

This study identifies DD-miRNAs as regulators of mitochondrial dysfunction in DMD, showing their upregulation and epigenetic control in dystrophic muscle.

Fast scanned widefield scheme provides tunable and uniform illumination for optimized SMLM on large fields of view

This paper introduces ASTER, a new illumination technique that enables uniform and tunable illumination for SMLM over large fields of view, improving imaging precision and throughput.

Nanometric axial localization of single fluorescent molecules with modulated excitation

This paper adapts a LIDAR-based excitation modulation technique to achieve nanometric axial localization in super-resolution microscopy with high precision and robustness.

Combining 3D single molecule localization strategies for reproducible bioimaging

This paper develops a 3D super-resolution imaging technique combining PSF shaping and SAF for improved axial localization and multicolor imaging.