Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation
N. C. Trendel, P. Kruger, S. Gaglione, J. Nguyen, J. Pettmann, E. D. Sontag, O. Dushek
The paper shows that partial TCR downregulation in T cells leads to perfect adaptation to constant antigen stimulation, which can be overcome by costimulation.
bioRxiv · Jul 16, 2019Immunology