Author

E. D. Sontag

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. L. Gevertz· 2 shared J. M. Greene· 2 shared A. L. Williams· 1 shared F. Ivich· 1 shared J. E. Fitzgerald· 1 shared J. Nguyen· 1 shared J. Pettmann· 1 shared M. Margaliot· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

J. L. Gevertz

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Author profile →

5 papers

Recent·Most cited

Short-term circulating tumor cell dynamics in mouse xenograft models and implications for liquid biopsy.

A. L. Williams, J. E. Fitzgerald, F. Ivich, E. D. Sontag, M. Niedre

This study uses DiFC to show that CTC numbers in mice fluctuate significantly over short timescales, challenging accurate enumeration from small blood samples.

bioRxiv · Jul 21, 2020Bioengineering

Validation of a Mathematical Model of Cancer Incorporating Spontaneous and Induced Evolution to Drug Resistance

J. L. Gevertz, J. M. Greene, E. D. Sontag

The paper validates a mathematical model of cancer that incorporates spontaneous and induced evolution to drug resistance using new experimental data.

bioRxiv · Dec 27, 2019 · PreprintCancer Biology

Compact attractors of an antithetic integral feedback system have a simple structure

M. Margaliot, E. D. Sontag

The paper analyzes the dynamics of an antithetic feedback system, showing that bounded trajectories satisfy a Poincare-Bendixson property, ruling out chaotic attractors.

bioRxiv · Dec 8, 2019 · PreprintBioengineering

Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation

N. C. Trendel, P. Kruger, S. Gaglione, J. Nguyen, J. Pettmann, E. D. Sontag, O. Dushek

The paper shows that partial TCR downregulation in T cells leads to perfect adaptation to constant antigen stimulation, which can be overcome by costimulation.

bioRxiv · Jul 16, 2019Immunology

A mathematical approach to differentiate spontaneous and induced evolution to drug resistance during cancer treatment

J. M. Greene, J. L. Gevertz, E. D. Sontag

This paper develops a mathematical model to differentiate between spontaneous and drug-induced resistance in cancer treatment and proposes an in vitro protocol to assess treatment-induced resistance.

bioRxiv · Jul 27, 2018Cancer Biology