N. Challagundla

IFNγ insufficiency during mouse intravaginal Chlamydia trachomatis infection exacerbates alternative activation in macrophages with compromised CD40 functions

This study shows that IFNγ insufficiency during chronic Chlamydia trachomatis infection in mice leads to alternatively activated macrophages with reduced CD40 expression, promoting immunosuppression and persistent infection.

microRNAs (miR 9, 124, 155 and 224) transdifferentiate macrophages to neurons

This paper demonstrates that miR 9, 124, 155, and 224 can transdifferentiate macrophages into neurons without exogenous transcription factors, achieving 18-21% efficacy and inducing neuronal markers and functional activity.