D. Shah

Harnessing Bilayer Biomaterial Delivery of FTY720 as an Immunotherapy to Accelerate Oral Wound Healing

Bilayer FTY720-nanofiber scaffolds promote complete oral wound closure in a mouse model by modulating pro-regenerative immune and stromal cells.

Small cationic cysteine-rich defensin-derived antifungal peptide controls white mold in soybean

The paper demonstrates that the GMA4CG_V6 peptide effectively controls white mold in soybean by reducing disease symptoms and sclerotia production without harming the plants.

IFNγ insufficiency during mouse intravaginal Chlamydia trachomatis infection exacerbates alternative activation in macrophages with compromised CD40 functions

This study shows that IFNγ insufficiency during chronic Chlamydia trachomatis infection in mice leads to alternatively activated macrophages with reduced CD40 expression, promoting immunosuppression and persistent infection.

Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

This study shows that heparan sulfate-dependent RAGE oligomerization is essential for RAGE signaling and demonstrates a monoclonal antibody that blocks this interaction.

Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery

This study investigates how redox conditions affect the structure and function of MIF, identifying redox-sensitive sites that modulate its interaction with CD74.

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

Medicago Sativa Defensin 1 (MsDef1), A Natural Tumor Targeted Sensitizer for Improving Chemotherapy: Translation from Anti-Fungal Agent to Potential Anti-Cancer Agent

This paper shows that MsDef1, a plant defensin, sensitizes drug-resistant cancer cells to chemotherapy by targeting two tumor-specific pathways.

Immuno-Phenotyping of High-Grade Glioma Infiltrating Immune Cells Reveals Grade Specific Differences in Cells of Myeloid Origin

The paper compares immune cell phenotypes in high-grade gliomas (grade III and IV) and finds differences in myeloid cell proportions and markers between tumor types and blood.

Robotic Assay for Drought (RoAD): An Automated Phenotyping System for Brassinosteroid and Drought Response

The paper introduces RoAD, a robotic system for automated BR and drought response experiments in Arabidopsis and maize, using imaging and machine learning to measure plant traits.

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

This study uses live-cell 3D single-molecule tracking to show that the NuRD complex decompacts chromatin and alters enhancer dynamics by increasing their movement and reducing time in a fast-diffusing state.

\"Viscotaxis\" - Directed Migration of Mesenchymal Stem Cells in Response to Loss Modulus Gradient

This study shows that human mesenchymal stem cells migrate from high to low loss modulus in response to viscous gradients, termed 'viscotaxis', and identifies cellular traction as the mechanism.

Antifungal potency and modes of action of a novel olive tree defensin against closely related ascomycete fungal pathogens

This study investigates the antifungal activity and mechanisms of a novel olive tree defensin against multiple ascomycete pathogens.

Impact of Ferumoxytol Magnetic Resonance Imaging on the Rhesus Macaque Maternal-Fetal Interface

Ferumoxytol-enhanced MRI does not affect histopathology or iron levels in the maternal-fetal interface of rhesus macaques during pregnancy or up to one year post-delivery.

Expression of ppsD, a gene involved in synthesis of Mycobacterium tuberculosis virulence factor PDIM, reflects treatment response in pulmonary tuberculosis patients

The paper examines ppsD gene expression in Mycobacterium tuberculosis clinical isolates to assess its correlation with treatment response and drug resistance acquisition.

β1 integrin is a sensor of blood flow direction

This study identifies β1 integrin as a sensor for blood flow direction in endothelial cells, showing it is activated by unidirectional but not bidirectional shear stress.