Ca2+-sensing receptor regulates neuronal excitability via Kv7 channel and Gi/o protein signalling
N. Chuinsiri, N. Siraboriphantakul, L. Kendall, P. Yarova, C. J. Nile, B. Song, I. Obara, J. Durham, V. Telezhkin
This study shows that the Ca2+-sensing receptor regulates neuronal excitability by inhibiting Kv7 channels through Gi/o protein signaling, offering a potential target for neuropathic pain treatment.
bioRxiv · Jul 7, 2023 · PreprintPhysiology