B. Song

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

Poxvirus A52 is a host range factor for modified vaccinia virus Ankara (MVA) and promotes viral replication by disturbing the formation of autolysosomes

This study identifies poxvirus protein A52 as a host range factor that disrupts autolysosome formation to promote viral replication in MVA.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

Differential seasonal effects of ephemeral legumes in response to moisture-nitrogen coupling in the deserts of northwestern China

This study examines how moisture and nitrogen affect two desert legumes, showing growth and chlorophyll differences under varying treatments, with moisture-nitrogen coupling influencing physiological responses.

Transposable element abundance subtly contributes to lower fitness in maize

This study quantifies the fitness costs of transposable elements in maize by analyzing TE content across thousands of inbred lines and linking TE accumulation to reduced grain yield.

Enhancement of Protein Stability by Quenching Millisecond Conformational Dynamics

This study links millisecond conformational dynamics of ubiquitin to protein stability through alanine mutations affecting the C-terminal retracted state.

Ca2+-sensing receptor regulates neuronal excitability via Kv7 channel and Gi/o protein signalling

This study shows that the Ca2+-sensing receptor regulates neuronal excitability by inhibiting Kv7 channels through Gi/o protein signaling, offering a potential target for neuropathic pain treatment.

Histone deacetylase 3 plays a critical role in hypertension-induced kidney inflammation and fibrosis

This study shows that myeloid HDAC3 deficiency protects against angiotensin II-induced kidney inflammation and fibrosis in mice.

A toxic ankyrin cysteine protease effector RipBH of brown rot triggered autophagy-associated cell death

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

Comparison between Canine and Porcine Models of Chronic Deep Venous Thrombosis

This study induces chronic deep venous thrombosis in canine and porcine models and compares their suitability for translational therapeutic research.

Resilient anatomy and local microplasticity of naïve and stress hematopoiesis

This study identifies durable microanatomical production lines in hematopoiesis that maintain blood cell production during stress and aging.

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery

A novel cryo-electron microscopy support film based on 2D crystal of HFBI protein

This paper introduces a new cryo-EM support film using HFBI protein 2D crystals to improve protein structure resolution by reducing preferred orientation and denaturation during vitrification.

A deep learning-based iterative digital pathology annotation tool

This paper introduces a deep learning-based tool for digital pathology annotation that reduces annotation time while maintaining accuracy, validated on CAMELYON16 and TCGA datasets.

Multispecies phase diagram of biofilm architectures reveals biophysical principles of biofilm development

The paper identifies two control parameters, cellular aspect ratio and cell density, that determine biofilm architecture across four bacterial species through experiments, simulations, and statistical analysis.

A novel method for generating 3D constructs with branched vascular networks using multi-materials bioprinting and direct surgical anastomosis

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

Gene expression evolution in pattern-triggered immunity within Arabidopsis thaliana and across Brassicaceae species

The paper identifies genes under purifying selection and species-specific expression signatures in PTI responses across Brassicaceae species using comparative transcriptomics.

Constrained non-coding sequence provides insights into regulatory elements and loss of gene expression in maize

The paper identifies constrained non-coding sequences in maize, showing their role in gene regulation and phenotypic variation through evolutionary analysis.

Physiological characterization of nitrate ammonifying bacteria isolated from rice paddy soils via a newly developed high-throughput screening method

This paper isolates and characterizes DNRA bacteria from rice paddy soils using a new high-throughput method, revealing a link between NO3- repression and C-to-N ratio regulation of DNRA activity.

Glucose Production and Glucose Disposal Integrated by an Intrinsic Inverse Coupling in Vivo: hypothesis of inter-organ reflex on glucose regulation

The paper demonstrates that glucose production and disposal are inversely coupled in vivo, regardless of insulin target site, and shows this coupling persists despite metabolic challenges.

Na2CO3-Responsive Photosynthetic and ROS Scavenging Mechanisms in Chloroplasts of Alkaligrass Revealed by Phosphoproteomics

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

A stable leading strand polymerase/clamp loader complex is required for normal and perturbed eukaryotic DNA replication

This study identifies the role of Ctf18-RFC in DNA replication by showing its interaction with DNA Pol ε and its function in fork protection and checkpoint signaling.

Flow-induced symmetry breaking in growing bacterial biofilms

This study investigates how fluid flow affects bacterial biofilm growth by combining live imaging and modeling, revealing three distinct growth phases and symmetry changes.

Computational fluid dynamics simulation of changes in the morphology and airflow dynamics of the upper airways in OSAHS patients after treatment with oral appliances

This study uses CFD simulations to analyze how oral appliances alter upper airway morphology and airflow dynamics in OSAHS patients, showing reduced resistance and improved patency.

Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

A weighted sequence alignment strategy for gene structure annotation lift over from reference genome to a newly sequenced individual

GEAN improves gene structure annotation lift over from a reference genome to newly sequenced individuals by addressing alignment inconsistencies through a weighted dynamic programming algorithm.

Enhanced nitrous oxide production in denitrifying Dechloromonas aromatica strain RCB under salt and alkaline conditions

This study examines how salt and alkaline stress affect N2O production and consumption in D. aromatica RCB, finding increased N2O accumulation under these conditions.

Cell rounding causes genomic instability by dissociation of single-stranded DNA-binding proteins

The paper identifies cell rounding as a source of genomic instability through DNA-binding protein dissociation, observed in normal, cancer, and stem cells.