Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue
F. R. Traube, N. F. Bras, W. P. Roos, C. C. Sommermann, T. Diehl, R. J. Mayer, A. R. Ofial, M. Müller, H. Zipse, T. Carell
This paper evaluates a stabilized carbocyclic Decitabine analogue, showing it effectively inhibits DNMT1 and induces more DNA damage in cancer cells with less toxicity.
bioRxiv · Jan 19, 2022Cancer Biology