M. Müller

Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani

This paper uses human induced pluripotent stem cell-derived macrophages to model Leishmania donovani infection and test drug efficacy, showing comparable results to mouse macrophages.

PHR1 and PHL1 mediate rapid high-light responses and acclimation to high photosynthetic activity

The paper investigates how PHR1 and PHL1 mediate plant responses to high light by regulating Pi signaling and lipid metabolism.

Functional comparisons of the virus sensor RIG-I from humans, the microbat Myotis daubentonii, and the megabat Rousettus aegyptiacus, and their response to SARS-CoV-2 infection

This study functionally compares RIG-I from microbats, megabats, and humans, showing similar antiviral function and SARS-CoV-2 sensing ability in humans and megabats but not microbats.

Differentiation and admixture of Fagus sylvatica L. and Fagus orientalis Lipsky in a northern German forest -- learning from pioneer forest work

The paper studies gene flow and admixture between Fagus sylvatica and Fagus orientalis in a German forest using molecular markers to determine the origin and direction of genetic exchange.

Heterogeneity in viral replication dynamics shapes the antiviral response

This study uses live-cell imaging to show that antiviral response activation varies in timing and strength based on viral replication dynamics and signaling pathway strength.

Influenza A Virus Exacerbates Group A Streptococcus Infection and Thwarts Anti-bacterial Inflammatory Responses in Murine Macrophages

This study shows that influenza A virus worsens Group A Streptococcus infection in mice by reducing anti-bacterial inflammatory responses in macrophages.

Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue

This paper evaluates a stabilized carbocyclic Decitabine analogue, showing it effectively inhibits DNMT1 and induces more DNA damage in cancer cells with less toxicity.

Interferons Reshape the 3D Conformation and Accessibility of Macrophage Chromatin

This study shows that type I and type II interferons induce similar epigenomic and transcriptional changes in macrophages, including 3D chromatin rearrangements and increased DNA accessibility at ISG loci.

Self-contained and modular structured illumination microscope

The paper introduces a modular structured illumination microscope (SIM) called HIT-SIM that enhances existing fluorescence microscopes with fast super-resolution imaging capabilities.

Exo-beta-N-acetylmuramidase NamZ of Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases

The paper identifies NamZ as an exo-{beta}-N-acetylmuramidase in Bacillus subtilis, showing its role in peptidoglycan degradation and proposing it as a founding member of a new family of hexosaminidases.

Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images

This paper develops a deep-learning method to denoise and reconstruct SR-SIM images, improving image quality and robustness across varying noise levels and microscope settings.

3D reconstruction of SARS-CoV-2 infection in ferrets emphasizes focal infection pattern in the upper respiratory tract

This study uses 3D imaging to show SARS-CoV-2 preferentially infects the upper respiratory tract of ferrets with a focal pattern in nasal turbinates.

Simulating digital micromirror devices for patterning coherent excitation light in structured illumination microscopy

This paper presents simulation frameworks for DMD-based illumination systems in structured illumination microscopy, addressing diffraction effects and system alignment.

DMD-based super-resolution structured illumination microscopy visualizes live cell dynamics at high speed and low cost

This paper develops a cost-effective, high-speed structured illumination microscopy system using DMDs and CMOS cameras to visualize live cell dynamics with super-resolution.

High speed multi-plane super-resolution structured illumination microscopy of living cells using an image-splitting prism

This paper introduces a multi-plane SR-SIM technique to enable fast 3D live cell imaging using an image-splitting prism and additional camera.

Chemical genetics of AGC-kinases reveals shared targets of Ypk1, Protein Kinase A and Sch9

The paper identifies shared targets of Ypk1, PKA, and Sch9 by comparing phospho-proteomes under chemical inhibition, revealing Ypk1's role in phosphorylating and activating Nth1.