Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism
B. P. Norman, A. S. Davison, J. H. Hughes, H. Sutherland, P. J. Wilson, N. G. Berry, A. T. Hughes, A. M. Milan, J. C. Jarvis, N. B. Roberts, L. R. Ranganath, G. Bou-Gharios, J. A. Gallagher
This study investigates the metabolic consequences of HGD deficiency in alkaptonuria, revealing new roles for phase I and II biotransformations in detoxifying endogenous metabolites.
bioRxiv · Apr 16, 2020 · PreprintBiochemistry