Author

J. C. Jarvis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

H. Sutherland· 3 shared A. M. Milan· 2 shared A. P. Sharples· 2 shared A. S. Davison· 2 shared A. T. Hughes· 2 shared B. P. Norman· 2 shared D. C. Hughes· 2 shared D. C. Turner· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

H. Sutherland

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bile is a route of excretion for homogentisic acid in alkaptonuria

B. P. Norman, H. Sutherland, P. J. Wilson, D. A. Rutland, A. M. Milan, A. T. Hughes, A. S. Davison, M. Khedr, J. C. Jarvis, J. A. Gallagher, G. Bou-Gharios, L. R. Ranganath

This study shows that bile excretes homogentisic acid in alkaptonuria mice, both on and off nitisinone treatment, revealing a new pathway for metabolite elimination.

bioRxiv · Dec 18, 2023 · PreprintBiochemistry

Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism

D. C. Turner, D. C. Hughes, L. M. Baehr, R. A. Seaborne, M. Viggars, J. C. Jarvis, P. P. Gorski, C. E. Stewart, D. J. Owens, S. C. Bodine, A. P. Sharples

This study shows that knocking down UBR5 leads to skeletal muscle atrophy by disrupting anabolic signaling pathways.

bioRxiv · Jun 5, 2020Cell Biology

Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism

B. P. Norman, A. S. Davison, J. H. Hughes, H. Sutherland, P. J. Wilson, N. G. Berry, A. T. Hughes, A. M. Milan, J. C. Jarvis, N. B. Roberts, L. R. Ranganath, G. Bou-Gharios, J. A. Gallagher

This study investigates the metabolic consequences of HGD deficiency in alkaptonuria, revealing new roles for phase I and II biotransformations in detoxifying endogenous metabolites.

bioRxiv · Apr 16, 2020 · PreprintBiochemistry

UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy

R. A. Seaborne, D. C. Hughes, D. C. Turner, D. J. Owens, L. M. Baehr, P. Gorski, E. A. Semenova, O. V. Borisov, A. K. Larin, D. V. Popov, E. V. Generozov, H. Sutherland, I. I. Ahmetov, J. C. Jarvis, S. C. Bodine, A. P. Sharples

This paper identifies UBR5 as a novel E3 ubiquitin ligase inversely regulated to MuRF1/MAFbx, epigenetically modulated during skeletal muscle recovery from atrophy and hypertrophy, and genetically associated with muscle fiber size and strength traits.

bioRxiv · Apr 29, 2019Physiology