Dual Dysfunction of Kir2.1 Underlies Conduction and Excitation-Contraction Coupling Defects Promoting Arrhythmias in a Mouse Model of Andersen-Tawil Syndrome Type 1
A. Macias, A. Gonzalez-Guerra, A. I. Moreno-Manuel, F. M. Cruz, N. Garcia-Quintans, L. K. Gutierrez, M. Roche-Molina, F. J. Bermudez-Jimenez, V. Andres, M. L. Vera-Pedrosa, I. Martinez-Carrascoso, J. A. Bernal, J. Jalife
This study identifies a dual dysfunction of Kir2.1 in a mouse model of ATS1, linking it to conduction and excitation-contraction coupling defects that promote arrhythmias.
bioRxiv · Jun 17, 2021 · PreprintCell Biology