N. Gundiah

Endothelial mechanobiology under controlled disturbed flows

This study develops a microfluidic device to generate controlled disturbed flows and shows how bidirectional oscillatory shear stress alters endothelial cell morphology and nuclear organization.

Heterogeneous identity, stiffness and growth characterise the shoot apex of Arabidopsis stem cell mutants

The paper investigates clavata mutant shoot apices in Arabidopsis, finding mechanical and functional heterogeneities that contribute to meristem overgrowth and buckling.

Golgi localized Arl15 regulates cargo transport, cell adhesion and motility

This study identifies Arl15's role in regulating cargo transport, cell adhesion, and motility by localizing it to the Golgi and cell surface, and shows its impact on filopodia and focal adhesion.

Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness

This study quantifies adhesion strength and tractions in cancer and non-cancer cells to correlate with invasiveness, showing invasive cells have lower adhesion strength and higher tractions.

Substrate stiffness modulates integrin α5 expression and ECM-associated gene expression in fibroblasts

This study shows that substrate stiffness affects integrin α5 and ECM-related gene expression in fibroblasts, influencing cell morphology, proliferation, and TGF-β signaling.

Physical biology of cell-substrate interactions under cyclic stretch

The paper develops a stochastic finite element model to study how cell-substrate interactions respond to substrate stiffness, ligand density, and cyclic stretch, showing biphasic traction responses and calcium-dependent mechanosensing.

Stress fiber growth and remodeling determines cellular morphomechanics under uniaxial cyclic stretch

This study investigates how stress fiber growth and remodeling affect cellular morphomechanics under uniaxial cyclic stretch, showing increased stiffness and reorientation.

Mechanics of wood boring by beetle mandibles

The paper analyzes the mechanics of wood boring by beetle mandibles, showing how their shape and material properties enable efficient wood fracturing and chip generation.