D. K. Saini

Anti-cancer drug Tamoxifen interferes with Mycobacterium tuberculosis PhoPR mediated signaling and inhibits mycobacterial growth

This study identifies Tamoxifen as an inhibitor of Mycobacterium tuberculosis PhoPR signaling, reducing bacterial growth and disrupting downstream gene expression.

The senescent mesothelial matrix accentuates colonization by ovarian cancer cells

This study shows that senescent mesothelial cells create a matrix that promotes ovarian cancer cell adhesion, spreading, and movement, enhancing metastasis.

Modulated protein-sterol interactions drive oxysterol-induced impaired CXCR4 signalling

This study investigates how oxysterols impair CXCR4 signaling by disrupting cholesterol-protein interactions and altering signaling residue conformations.

An evolutionary paradigm favoring crosstalk between bacterial two-component signaling systems

This paper proposes an evolutionary paradigm where crosstalk between bacterial two-component signaling systems can be advantageous in programmed environments, supported by simulations and data from Mycobacterium tuberculosis.

Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness

This study quantifies adhesion strength and tractions in cancer and non-cancer cells to correlate with invasiveness, showing invasive cells have lower adhesion strength and higher tractions.

Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples

This study identifies prognostic markers and therapeutic targets for COVID-19 by analyzing Omics data from nasal and BALF samples, finding S100 family genes and TXN as key factors, and validating Auranofin as a potential treatment.

Aging associated altered response to intracellular bacterial infections and its implication on the host

The paper shows that aging enhances innate immune responses to bacterial infections in mice but persistent inflammation leads to host mortality.

The histidine kinase PdtaS is a cyclic di-GMP binding metabolic sensor that controls mycobacterial adaptation to nutrient deprivation

The paper identifies PdtaS as a c-di-GMP binding histidine kinase that regulates mycobacterial adaptation to nutrient deprivation through transcriptional and metabolic changes.