Author

N. J. Coleman

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Biochemistry· 1

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Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. Bobkov· 1 shared A. L. Cooksy· 1 shared B. M. Conley· 1 shared C. D. Sohl· 1 shared D. A. Matteo· 1 shared E. A. Komives· 1 shared E. Albekioni· 1 shared J. M. Schiffer· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. A. Bobkov

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1 paper

Recent·Most cited

Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms

M. Mealka, N. A. Sierra, D. A. Matteo, E. Albekioni, R. Khoury, T. Mai, B. M. Conley, N. J. Coleman, K. A. Sabo, E. A. Komives, A. A. Bobkov, A. L. Cooksy, S. Silletti, J. M. Schiffer, T. Huxford, C. D. Sohl

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

bioRxiv · Jan 10, 2024Biochemistry