Author

J. M. Schiffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. Bobkov· 2 shared C. D. Sohl· 2 shared A. Hoang· 1 shared A. L. Cooksy· 1 shared B. M. Conley· 1 shared D. A. Matteo· 1 shared D. A. Scott· 1 shared D. G. Isom· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

A. A. Bobkov

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Author profile →

2 papers

Recent·Most cited

Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms

M. Mealka, N. A. Sierra, D. A. Matteo, E. Albekioni, R. Khoury, T. Mai, B. M. Conley, N. J. Coleman, K. A. Sabo, E. A. Komives, A. A. Bobkov, A. L. Cooksy, S. Silletti, J. M. Schiffer, T. Huxford, C. D. Sohl

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

bioRxiv · Jan 10, 2024Biochemistry

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

L. A. Luna, Z. Lesecq, K. A. White, A. Hoang, D. A. Scott, O. Zagnitko, A. A. Bobkov, D. L. Barber, J. M. Schiffer, D. G. Isom, C. D. Sohl

This paper identifies an acidic residue in IDH1 that regulates catalysis and pH sensitivity through conformational changes.

bioRxiv · Apr 19, 2020Biochemistry