Author

N. J. Thomson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:electrophysiology· 1 Organism:human· 1

Frequent Co-Authors

U. Zachariae· 4 shared C. M. Ives· 3 shared A. T. Sahin· 1 shared O. N. Vickery· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 5 mutual co-author links

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4 shared papersBiophysics

U. Zachariae

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4 papers

Recent·Most cited

Mechanism of negative μ-opioid receptor modulation by sodium ions

N. J. Thomson, U. Zachariae

This study investigates how sodium ions negatively modulate μ-opioid receptors by analyzing molecular dynamics simulations and revealing structural changes linked to Na+ binding.

bioRxiv · Jun 15, 2023 · PreprintBiophysics

A hydrophobic funnel governs monovalent cation selectivity in the ion channel TRPM5

C. M. Ives, A. T. Sahin, N. J. Thomson, U. Zachariae

This study identifies a hydrophobic funnel in TRPM5 that enables monovalent cation selectivity by blocking divalent cations through a unique mechanism.

bioRxiv · Jan 11, 2023Biophysics

A co-operative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels

C. M. Ives, N. J. Thomson, U. Zachariae

This study investigates how TRPV channels achieve Ca2+-selectivity through a co-operative knock-on mechanism and structural differences.

bioRxiv · Apr 1, 2022 · PreprintBiophysics

Ion-water coupling controls class A GPCR signal transduction pathways

N. J. Thomson, O. N. Vickery, C. M. Ives, U. Zachariae

The paper uses molecular dynamics simulations to show that ion-water coupling is essential for GPCR signal transduction, with sodium acting as a master switch.

bioRxiv · Aug 28, 2020 · PreprintBiophysics