Author

C. M. Ives

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:protein folding & dynamics· 4 Approach:deep learning· 3 Assay:electrophysiology· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Assay:structural biology· 3

Frequent Co-Authors

U. Zachariae· 6 shared N. J. Thomson· 3 shared A. M. Harbison· 2 shared C. A. Fogarty· 2 shared E. Fadda· 2 shared A. Bartsch· 1 shared A. Bizior· 1 shared A. Javelle· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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6 shared papersBiophysics

U. Zachariae

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Author profile →

8 papers

Recent·Most cited

Restoring Protein Glycosylation with GlycoShape

C. M. Ives, O. Singh, S. D'Andrea, C. A. Fogarty, A. M. Harbison, A. Satheesan, B. Tropea, E. Fadda

The paper introduces GlycoShape, an open-access database and tool to restore glycosylation to protein structures using molecular dynamics simulations and public structural data.

Nature Methods · Oct 14, 2024Peer-reviewedBiophysics

GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern

C. M. Ives, L. Nguyen, C. A. Fogarty, A. M. Harbison, Y. Durocher, J. S. Klassen, e. fadda

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

bioRxiv · Dec 5, 2023Biophysics

A hydrophobic funnel governs monovalent cation selectivity in the ion channel TRPM5

C. M. Ives, A. T. Sahin, N. J. Thomson, U. Zachariae

This study identifies a hydrophobic funnel in TRPM5 that enables monovalent cation selectivity by blocking divalent cations through a unique mechanism.

bioRxiv · Jan 11, 2023Biophysics

The SARS-CoV-2 envelope (E) protein forms a calcium- and voltage-activated calcium channel

L. H. Antonides, Q. W. Hurst, C. M. Ives, K. Ramberg, N. Ostrovitas, E. Scanlan, M. Caffrey, S. J. Pitt, U. Zachariae

This study identifies the SARS-CoV-2 E protein as a calcium- and voltage-activated ion channel that releases Ca2+ from the ER, suggesting it as a potential target for antiviral therapies.

bioRxiv · Oct 11, 2022 · PreprintBiophysics

A co-operative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels

C. M. Ives, N. J. Thomson, U. Zachariae

This study investigates how TRPV channels achieve Ca2+-selectivity through a co-operative knock-on mechanism and structural differences.

bioRxiv · Apr 1, 2022 · PreprintBiophysics

An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding

A. Bartsch, C. M. Ives, C. Kattner, F. Pein, M. Tanabe, A. Munk, U. Zachariae, C. Steinem, S. Llabres

This study shows how a single mutation in Neisseria meningitidis porin PorB affects antibiotic binding and permeability, revealing structural and functional changes in drug resistance.

bioRxiv · Nov 6, 2020Biophysics

Ion-water coupling controls class A GPCR signal transduction pathways

N. J. Thomson, O. N. Vickery, C. M. Ives, U. Zachariae

The paper uses molecular dynamics simulations to show that ion-water coupling is essential for GPCR signal transduction, with sodium acting as a master switch.

bioRxiv · Aug 28, 2020 · PreprintBiophysics

A two-lane mechanism for selective biological ammonium transport

G. Williamson, G. Tamburrino, G. Dias Mirandela, M. Boeckstaens, M. Bade, A. Pisliakov, C. M. Ives, E. Terras, A. Bizior, P. A. Hoskisson, A.-M. Marini, U. Zachariae, A. Javelle

The paper reveals a two-lane mechanism for selective ammonium transport in Amt/Mep/Rh transporters using electrophysiology, yeast complementation, and molecular dynamics simulations.

bioRxiv · Nov 20, 2019Biochemistry