Author

A. T. Sahin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1

Frequent Co-Authors

U. Zachariae· 2 shared A. Armutlu· 1 shared A. L. Ryan· 1 shared A. Senturk· 1 shared A. van der Does· 1 shared A. van Schadewijk· 1 shared B. Calvert· 1 shared C. M. Ives· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

U. Zachariae

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure-function relationships of mucociliary clearance in human and rat airways

D. Roth, A. T. Sahin, F. Ling, N. Tepho, C. Senger, E. Quiroz, B. Calvert, A. van der Does, T. G. Güney, S. Glasl, A. van Schadewijk, L. von Schledorn, R. Olmer, E. Kanso, J. C. Nawroth, A. L. Ryan

The paper compares mucociliary clearance in human and rat airways, finding species-specific structural differences that affect clearance effectiveness and identifying limitations of lab-grown cultures.

bioRxiv · Dec 24, 2023Biophysics

Characterisation of ligand gating, ion conduction and the ion selectivity mechanism in the endo-lysosomal ion channel hTPC2

A. T. Sahin, U. Zachariae

This study uses simulations to investigate how the lipid PI(3,5)P2 affects ion selectivity and activation of hTPC2, revealing structural changes and ion permeation mechanisms.

bioRxiv · Nov 1, 2023 · PreprintBiophysics

A hydrophobic funnel governs monovalent cation selectivity in the ion channel TRPM5

C. M. Ives, A. T. Sahin, N. J. Thomson, U. Zachariae

This study identifies a hydrophobic funnel in TRPM5 that enables monovalent cation selectivity by blocking divalent cations through a unique mechanism.

bioRxiv · Jan 11, 2023Biophysics

Quantitative proteomics identifies secreted diagnostic biomarkers as well as tumor-dependent prognostic targets for clear cell Renal Cell Carcinoma

A. Senturk, A. T. Sahin, A. Armutlu, M. C. Kiremit, O. Acar, S. Erdem, S. Bagbudar, T. Esen, N. Tuncbag, N. Ozlu

The paper uses quantitative proteomics to identify secreted biomarkers and prognostic targets in ccRCC, finding SPARC as a promising diagnostic marker and proposing a biomarker panel for prognosis.

bioRxiv · Feb 8, 2021Cancer Biology