Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2
Y. Suo, N. J. Wright, H. Guterres, J. G. Fedor, K. J. Butay, M. J. Borgnia, W. Im, S.-Y. Lee
The paper presents cryo-EM structures of OCT1 and OCT2 in different states and combines them with functional experiments to reveal principles of organic cation recognition and the alternating access mechanism.
bioRxiv · Mar 15, 2023Biophysics