Author

H. Guterres

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Mattos· 1 shared D. P. Donnelly· 1 shared J. A. Parker· 1 shared J. G. Fedor· 1 shared J. K. Chung· 1 shared J. N. Agar· 1 shared J. T. Groves· 1 shared K. J. Butay· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

C. Mattos

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2 papers

Recent·Most cited

Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2

Y. Suo, N. J. Wright, H. Guterres, J. G. Fedor, K. J. Butay, M. J. Borgnia, W. Im, S.-Y. Lee

The paper presents cryo-EM structures of OCT1 and OCT2 in different states and combines them with functional experiments to reveal principles of organic cation recognition and the alternating access mechanism.

bioRxiv · Mar 15, 2023Biophysics

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

M. Packer, J. A. Parker, J. K. Chung, Z. Li, Y. K. Lee, T. Cookis, H. Guterres, S. Alvarez, M. A. Hossain, D. P. Donnelly, J. N. Agar, L. Makowski, M. Buck, J. T. Groves, C. Mattos

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Proceedings of the National Academy of Sciences · Mar 9, 2021Peer-reviewedBiophysics