N. K. Sharma

Analytical code sharing practices in biomedical research

This study analyzes code sharing practices in biomedical research and finds that less than half of manuscripts share analytical code, with significant associations between code availability statements and actual code sharing.

MicroRNA397 regulates tolerance to drought and fungal infection by regulating lignin deposition in chickpea root

This study shows that microRNA397 regulates lignin deposition in chickpea roots, affecting drought and fungal infection tolerance.

Development of an Agrobacterium-delivered codon-optimized CRISPR/Cas9 system for chickpea genome editing

This paper develops a codon-optimized CRISPR/Cas9 system delivered by Agrobacterium for chickpea genome editing, achieving 42% editing efficiency in PDS mutants.

An intracellular tripeptide Arg-His-Trp of serum origin detected in MCF-7 cells is a possible agonist to β2 adrenoceptor

This paper identifies a tripeptide Arg-His-Trp from serum as a potential agonist of β2 adrenoceptor with binding affinity comparable to isoproterenol.

Novel antiproliferative tripeptides block AP-1 transcriptional complex by in silico approach

This study identifies novel tripeptides from goat urine that inhibit the AP-1 transcriptional complex, leading to reduced proliferation in HCT-116 cells.

Distinct DNA metabolism and anti-proliferative effects of goat urine metabolites: An explanation for xeno-tumor heterogeneity

This study shows goat urine metabolites have strong DNA metabolizing and anti-proliferative effects on cancer cells, potentially explaining rare tumor types in goats.

Detection of urinary metabolites of metabolic pathway disorders by using VTGE and LC-HRMS techniques

The paper introduces a method combining VTGE and LC-HRMS to detect metabolites in urine for metabolic disorder diagnosis, showing its effectiveness in identifying specific biomarkers.

A novel method to detect intracellular metabolite alterations in MCF-7 cells by doxorubicin induced cell death

This paper identifies key intracellular metabolite changes in MCF-7 cells treated with doxorubicin using a novel vertical tube gel electrophoresis (VTGE) system and LC-HRMS analysis, revealing caspase 3-independent mitochondrial apoptosis.