S. Yadav

Isogenic iPSC-derived proximal and distal lung-on-chip models: Tissue- and virus-specific immune responses in human lungs

The paper develops isogenic lung-on-chip models from iPSC-derived cells to study tissue-specific immune responses to SARS-CoV-2 and Influenza viruses.

Factors affecting macromolecule orientations in thin films formed in cryo-EM

This study investigates factors affecting macromolecule orientations in cryo-EM thin films and identifies parameters to reduce orientation bias.

Myeloid Drp1 Deficiency Limits Revascularization in Ischemic Muscles via Inflammatory Macrophage Polarization and Metabolic Reprograming

This study shows that myeloid Drp1 deficiency impairs revascularization in ischemic muscle by promoting pro-inflammatory macrophage polarization and metabolic reprogramming.

Organic matter degradation in the deep, sulfidic waters of the Black Sea: Insights into the ecophysiology of novel anaerobic bacteria

This study cultivates and characterizes novel anaerobic bacteria from deep sulfidic Black Sea waters, revealing their specialized roles in organic matter degradation.

Progesterone induces meiosis through two obligate co-receptors with PLA2 activity

This study identifies ABHD2 as an essential co-receptor for mPRβ to trigger meiosis via PLA2 activity in Xenopus oocytes.

The bi-directional extracellular electron transfer process aids iron cycling by Geoalkalibacter halelectricus in a highly saline-alkaline condition

This study demonstrates that Geoalkalibacter halelectricus performs bi-directional extracellular electron transfer to cycle iron in highly saline-alkaline environments.

Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis

This study identifies the PPE50-PPE51 gene cluster in M. tuberculosis as promoting bacillary persistence through TLR1-dependent immunomodulation, reducing intracellular viability and increasing anti-inflammatory cytokine levels.

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Zinc nano-fertilization enhances wheat productivity and biofortification

This study evaluates zinc oxide nanoparticles (ZnO-NPs) and zinc sulfate (ZnSO4) on wheat growth, yield, and grain zinc concentration, finding ZnO-NPs more effective for biofortification and yield enhancement.

MicroRNA397 regulates tolerance to drought and fungal infection by regulating lignin deposition in chickpea root

This study shows that microRNA397 regulates lignin deposition in chickpea roots, affecting drought and fungal infection tolerance.

Fine-scale variability in coral bleaching and mortality during a marine heatwave

This study tracks coral bleaching and mortality during a marine heatwave, finding that spatial and taxonomic differences in bleaching are driven by environmental factors, habitat complexity, and species composition.

Lithography-less, frugal and long-term diffusion-based static gradient generating microfluidic device for high-throughput drug testing

This paper presents a microfluidic device for drug testing that generates stable concentration gradients without requiring complex fabrication or accessories, validated with drug efficacy tests on cancer cells.

Scalable large-area mesh-structured microfluidic gradient generator for drug testing applications

This paper develops a cost-effective, scalable microfluidic gradient generator for drug testing, validated with curcumin on HeLa cells, showing comparable IC50 values to conventional methods.

Imaging the structure and dynamic activity of retinal microglia and macrophage-like cells in the living human eye

This paper introduces a fiber-bundle adaptive optics scanning light ophthalmoscopy (FB-AOSLO) method to image retinal microglia and macrophage-like cells in living eyes, showing increased speed and dynamic activity monitoring.

Single-cell genetic heterogeneity linked to immune infiltration in glioblastoma.

The paper links genetic heterogeneity in glioblastoma to immune infiltration by analyzing single-cell genomic and spatial data.

Bacterial keratitis: similar bacterial and clinical outcomes in female versus male New Zealand White rabbits infected with Serratia marcescens

This study finds no significant difference in bacterial burden or corneal scores between male and female rabbits infected with Serratia marcescens, suggesting mixed-sex groups can be used in bacterial keratitis research.

TAOK2 is an ER-localized Kinase that Catalyzes the Dynamic Tethering of ER to Microtubules

This study identifies TAOK2 as an ER-microtubule tether and shows its kinase activity regulates ER dynamics and cell division.

Auxin-responsive (phospho)proteome analysis reveals regulation of cell cycle and ethylene signaling during rice crown root development

Response of rhizobial strains on biochemical traits and nutrient uptake in Mungbean (Vigna radiata L. Wilczek) under moisture stress

The study evaluates the impact of rhizobial inoculation on biochemical traits and nutrient uptake in mungbean under moisture stress conditions.

Rare genera differentiate urban green space soil bacterial communities in three cities across the world

The paper examines the relationship between vegetation complexity and soil bacterial communities in urban green spaces across three cities, finding that rare genera significantly differ between vegetation complexity categories.

MicroRNA775 and target Galactosyltransferase (GALT9) module regulates recovery from submergence induced senescence by modulating SAGs in Arabidopsis thaliana

This study identifies miR775 and its target GALT9 as regulators of submergence-induced senescence recovery in Arabidopsis by modulating SAGs and ROS levels.

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

Metabolomics shows the Australian dingo has a unique plasma profile

The study compares plasma metabolomes of dingoes, domestic dogs, and their hybrids, finding significant differences between dingoes and domestic dogs but not between hybrids and dingoes.

Local auxin biosynthesis promotes shoot patterning and stem cell differentiation in Arabidopsis shoot apex

The paper shows that auxin biosynthesis by TAA1 and TAR2 in Arabidopsis SAM is essential for patterning the central and peripheral zones and differentiation of stem cells into specific cell types.

Breaking a Strong Amide Bond: Structure and Properties of Dimethylformamidase.

This paper describes the structure and properties of Dimethylformamidase (DMFase) from Paracoccus, revealing new protein folds and a unique mononuclear iron active site that enables its function in harsh conditions.