S. K. Gupta

A tomato ethylene-insensitive mutant displays altered growth and higher β-carotene levels in fruit

Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA

This study shows that Msi2 induces cardiac hypertrophy and heart failure by causing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.

Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

MicroRNA397 regulates tolerance to drought and fungal infection by regulating lignin deposition in chickpea root

This study shows that microRNA397 regulates lignin deposition in chickpea roots, affecting drought and fungal infection tolerance.

Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

This study shows that Salmonella modulates SIRT1 and SIRT3 to maintain its metabolism and promote pathogenesis by altering host macrophage polarization and metabolism.

Development of an Agrobacterium-delivered codon-optimized CRISPR/Cas9 system for chickpea genome editing

This paper develops a codon-optimized CRISPR/Cas9 system delivered by Agrobacterium for chickpea genome editing, achieving 42% editing efficiency in PDS mutants.

Biochemical analysis of anthocyanin and proanthocyanidin and their regulation in determining chickpea flower and seed coat colours

This study identifies CaMATE1 and CabHLH as regulators of flower and seed coat color in chickpea by manipulating gene expression in a desi genotype.

Loss-of-function mutations in novel triacylglycerol lipase genes are associated with low rancidity in pearl millet flour

Proinflammatory innate cytokines and metabolomic signatures shape the T cell response in active COVID-19

The paper examines how proinflammatory cytokines and metabolomic signatures influence T cell responses in active COVID-19 patients, showing preserved T cell responses against variants despite reduced antibody responses.

Fast and cost-effective age estimation in Bengal tiger and Asiatic lion: applicability of cementum analysis method

This paper describes a fast and cost-effective age estimation method for Bengal tigers and Asiatic lions using cementum analysis of incisor teeth.

Horn trophy seized in illegal wildlife trade assigned to swamp buffalo using a combined morphometric and DNA based approach in wildlife forensics in India

The paper identifies a seized horn as belonging to a swamp buffalo using morphometric and DNA analysis, providing a protocol for species identification in wildlife forensics.

Ecological memory of prior nutrient exposure in the human gut microbiome

The paper shows the human gut microbiome retains a memory of past carbohydrate exposures, enhancing future metabolic responses through rapid transcriptional changes.

MITOCHONDRIAL GENOME REVEALS CONTRASTING PATTERN OF ADAPTIVE SELECTION IN TURTLES AND TORTOISES

The paper analyzes mitochondrial genomes of turtles and tortoises to compare adaptive selection patterns, finding stronger positive selection in turtles than tortoises.

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

This study shows that SARS-CoV-2 infection in golden Syrian hamsters causes lung and cardiovascular pathologies similar to human COVID-19, suggesting GSH as a model for studying long-term effects.

Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

Phylogeography and population genetic structure of red muntjacs: Evidence of enigmatic Himalayan red muntjac from India

This study identifies a new mitochondrial lineage of red muntjac in Northwest India, revealing three genetic clusters and suggesting conservation actions for the Himalayan red muntjac.

Genetic diversity of clinical Bordetella pertussis ST2 strains in comparison with vaccine reference strains of India

The paper reports complete genomes of two clinical B. pertussis ST2 strains from India, revealing genome degradation and virulence traits compared to vaccine reference strains.