Inhibition of HIV-1 immune modulation by small molecules targeting viral Nef-host CD80 interface
A. U. Sharma, S. Sharma, G. Arumugam, A. P. Nair, S. Ambala, G. Munagala, K. R. Yempalla, A. Munjal, S. Rajkumar, N. Kamariah, S. Ramanathan, T. Saiyed, A. R. Venkitaraman, P. P. Singh, R. Vishwakarma, , A. S. Karumbati
The paper identifies small molecules that inhibit HIV-1 Nef's down-regulation of CD80/86, restoring T-cell activation by targeting the Nef-CD80 interface.
bioRxiv · Sep 7, 2021 · PreprintMicrobiology