A. R. Venkitaraman

Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents

The paper develops selective Aurora A-TPX2 inhibitors that show in vivo efficacy and synergy with paclitaxel in pancreatic cancer.

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

This study shows that a ketogenic diet slows tumor growth but accelerates cachexia and shortens survival in IL-6-driven cancer models by inducing ferroptosis and corticosterone deficiency.

Inhibition of HIV-1 immune modulation by small molecules targeting viral Nef-host CD80 interface

The paper identifies small molecules that inhibit HIV-1 Nef's down-regulation of CD80/86, restoring T-cell activation by targeting the Nef-CD80 interface.

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

The paper shows that early neutrophilia driven by aerobic glycolysis supports host metabolism and delays cancer cachexia in murine models.

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

Structural features underlying the activity of benzimidazole derivatives that target phosphopeptide recognition by the tandem BRCT domain of the BRCA1 protein

This paper identifies structural features of Bractoppin, a benzimidazole inhibitor of BRCA1 tBRCT phosphopeptide recognition, through chemical modifications and biochemical assays.

Enhancing biochemical resolution by hyper-dimensional imaging microscopy

This paper introduces HDIM, a new imaging technique that enhances biochemical resolution in fluorescence microscopy by simultaneously quantifying multiple orthogonal properties of fluorescence emission.