Author

N. Khakhum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:protein sequence· 1

Frequent Co-Authors

A. G. Torres· 4 shared J. L. Stockton· 3 shared A. Adam· 1 shared A. Huerta-Saquero· 1 shared A. J. Badten· 1 shared D. Tapia· 1 shared H. L. Stevenson· 1 shared I. G. Chapartegui-Gonzalez· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

A. G. Torres

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Author profile →

4 papers

Recent·Most cited

Contribution of the Type 6 Secretion System to Apoptosis and Macrophage Polarization During Burkholderia pseudomallei Infection

J. L. Stockton, N. Khakhum, A. G. Torres

This study shows the Type 6 Secretion System (T6SS) in Burkholderia pseudomallei increases apoptosis and inflammatory nodule severity during infection, while not affecting macrophage polarization.

bioRxiv · Mar 1, 2024 · PreprintMicrobiology

Decoration of Burkholderia Hcp1 protein to virus-like particles as a vaccine delivery platform.

N. Khakhum, N. Baruch-Torres, J. L. Stockton, I. G. Chapartegui-Gonzalez, A. J. Badten, A. Adam, T. Wang, A. Huerta-Saquero, W. Yin, A. G. Torres

This study conjugates Hcp1 protein to P22 VLPs to create a vaccine platform, inducing antibody responses and enhancing macrophage phagocytosis in mice.

bioRxiv · Jan 17, 2024 · PreprintMicrobiology

Burkholderia pseudomallei BicA protein promotes pathogenicity in macrophages by regulating Invasion, Intracellular Survival, and Virulence.

J. L. Stockton, N. Khakhum, H. L. Stevenson, A. G. Torres

This study identifies BicA as a regulator of virulence in Burkholderia pseudomallei by affecting intracellular survival, dissemination, and secretion system expression in macrophages.

bioRxiv · Jul 10, 2023 · PreprintMicrobiology

Dual RNA-seq reveals a type 6 secretion system-dependent blockage of TNF-α signaling and BicA as a Burkholderia pseudomallei virulence factor important during gastrointestinal infection

J. I. Sanchez-Villamil, D. Tapia, N. Khakhum, S. G. Widen, A. G. Torres

This study identifies the type 6 secretion system (T6SS) and the BicA gene as critical for Burkholderia pseudomallei virulence during gastrointestinal infection using dual RNA-seq and mutant analysis.

bioRxiv · Apr 22, 2022Microbiology