Author

S. G. Widen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:host-pathogen & immune response· 3 Organism:Arabidopsis· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

H. Xia· 2 shared P.-Y. Shi· 2 shared X. Xie· 2 shared A. Accoti· 1 shared A. E. I. Abu· 1 shared A. G. Torres· 1 shared B. A. Johnson· 1 shared B. Kalveram· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

H. Xia

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Author profile →

6 papers

Recent·Most cited

Dehydration induced AePer50 regulates midgut infection in Aedes aegypti

A. Accoti, M. Becker, A. E. I. Abu, J. Vulcan, R. Yun, S. G. Widen, M. Sylla, V. L. Popov, S. C. Weaver, L. B. Dickson

This study identifies AePer50, a gene upregulated during dehydration in Aedes aegypti, as critical for midgut infection of arboviruses under low humidity conditions.

bioRxiv · Oct 11, 2023 · PreprintMicrobiology

Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages

H. Xia, J. Yeung, B. Kalveram, C. J. Bills, J. Y.-C. Chen, C. Kurhade, j. Zou, S. G. Widen, B. R. Mann, R. J. Kondor, T. C. Davis, B. Zhou, D. E. Wentworth, X. Xie, P.-Y. Shi

This study examines the replication and cross-neutralization of SARS-CoV-2 Omicron sublineages in mice and human airway cultures, finding distinct antigenic profiles and bivalent vaccine support.

bioRxiv · Nov 8, 2022Microbiology

Dual RNA-seq reveals a type 6 secretion system-dependent blockage of TNF-α signaling and BicA as a Burkholderia pseudomallei virulence factor important during gastrointestinal infection

J. I. Sanchez-Villamil, D. Tapia, N. Khakhum, S. G. Widen, A. G. Torres

This study identifies the type 6 secretion system (T6SS) and the BicA gene as critical for Burkholderia pseudomallei virulence during gastrointestinal infection using dual RNA-seq and mutant analysis.

bioRxiv · Apr 22, 2022Microbiology

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

Y. Liu, J. Liu, B. A. Johnson, H. Xia, Z. Ku, C. Schindewolf, S. G. Widen, Z. An, S. Weaver, V. D. Menachery, X. Xie, P.-Y. Shi

This study identifies the P681R mutation in the Delta variant's spike protein as critical for enhanced viral replication compared to the Alpha variant through increased furin cleavage of the spike protein.

bioRxiv · Aug 12, 2021Microbiology

Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness

S. L. P. Scroggs, J. T. Gass, R. Chinnasamy, S. G. Widen, S. R. Azar, S. L. Rossi, J. B. Arterburn, N. Vasilakis, K. A. Hanley

This study investigates resistance to fluoroquinolones in dengue virus serotype 4 and finds that resistance mutations affect viral fitness and binding/entry mechanisms.

bioRxiv · May 11, 2020Evolutionary Biology

Global transcriptome analysis of Aedes aegypti mosquitoes in response to Zika virus infection

K. Etebari, S. Hegde, M. A. Saldana, S. G. Widen, T. G. Wood, S. Asgari, G. L. Hughes

This study analyzes the transcriptome of Aedes aegypti mosquitoes infected with Zika virus at 2, 7, and 14 days post-infection, identifying changes in transcripts and long intergenic non-coding RNAs.

bioRxiv · Oct 27, 2017Microbiology