A two-component protein condensate of EGFR and Grb2 regulates Ras activation at the membrane
C.-W. Lin, L. M. Nocka, B. Stinger, J. DeGrandchamp, N. Lew, S. Alvarez, H. Phan, Y. Kondo, J. Kuriyan, J. T. Groves
This study shows that EGFR and Grb2 form a condensate that regulates Ras activation through phosphorylation and dimerization.
bioRxiv · Dec 12, 2021 · PreprintBiophysics