S. Alvarez

Microfabrication-based engineering of biomimetic dentin-like constructs to simulate dental aging

This study develops a microfabricated biomimetic dentin model to simulate dental aging and test oral biofilm formation.

Nitrogen starvation leads to TOR kinase-mediated downregulation of fatty acid synthesis in the algae Chlorella sorokiniana and Chlamydomonas reinhardtii

The paper shows nitrogen starvation reduces fatty acid synthesis in algae via TOR kinase, and this effect is conserved between two algal species.

Bimodality in Ras signaling originates from processivity of the Ras activator SOS without classic kinetic bistability

The paper shows that Ras signaling bimodality arises from SOS processivity, not kinetic bistability, and is controlled by scaffold protein condensation.

In vivo functional phenotypes from a computational epistatic model of evolution

The paper develops a computational model to evolve functional protein variants in E. coli, showing that epistatic constraints can generate active beta-lactamase variants with enhanced activity.

Extracellular Vesicles derived from Apis mellifera Royal Jelly promote wound healing by modulating inflammation and cellular responses

Variation in morpho-physiological and metabolic responses to low nitrogen stress across the sorghum association panel

The paper quantifies variation in sorghum's morphological, physiological, and metabolic responses to nitrogen stress and links these to grain yield under different conditions.

Functional Requirements for a Samd14-Capping Protein Complex in Stress Erythropoiesis

This study identifies a Samd14-CP complex interaction that promotes stress erythropoiesis by enhancing SCF/c-Kit signaling in erythroid precursors.

A two-component protein condensate of EGFR and Grb2 regulates Ras activation at the membrane

This study shows that EGFR and Grb2 form a condensate that regulates Ras activation through phosphorylation and dimerization.

Natural variation in root exudation of GABA and DIMBOA impacts the maize root endosphere and rhizosphere microbiomes

This study shows that natural variation in maize root exudates of GABA and DIMBOA affects rhizosphere and root endosphere microbiomes, with specific impacts on bacterial families and metatranscriptomic pathways.

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Potent, specific MEPicides for treatment of zoonotic staphylococci

This paper identifies DXR as a druggable target for zoonotic staphylococci and develops potent prodrug inhibitors (MEPicides) that bypass transporter requirements.

Comparative genomics and phylogeny of sequenced IncHI plasmids

This study compares 44 IncHI plasmid sequences to analyze their evolutionary relationships and functional features, revealing divergence times and horizontal/vertical transfer mechanisms.

Cross-Species Complementation Reveals Conserved Functions For EARLY FLOWERING 3 Between Monocots And Dicots

The paper functionally complements Arabidopsis ELF3 with orthologs from Brachypodium and Setaria, showing conserved molecular and physiological roles despite sequence divergence.